In transgender women who have had their testes removed as part of the gender-affirming process, a form of estrogen called estradiol strengthens connections between areas of the brain involved in fine motor skills, learning, emotions and sensory perception, according a study to be presented Monday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La. These findings reflect changes on the brain that might have implications, for instance, for treating hot flashes and other symptoms in transgender women, the researchers say.
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